It inhibits nucleic acid synthesis by forming nitroso radicals , which disrupt the dna of microbial cells. The mechanism of action involves concentration in the parasite but the exact mechanism is unknown. Por, which may be detected by measuring the coenzyme a.
Metronidazole (Antiamoebic Drugs) Mechanism of Action
Metronidazole is activated when reduced, and reduction occurs only under strongly reducing conditions (28, 43).
Mechanism of action of metronidazole metronidazole is nitro imidazoles which have broad spectrum cidal activity against protozoa and some anaerobic bacteria.
The toxicity of the intermediates is due to their interaction with deoxyri. It is believed that it may inhibit heme polymerization with a final result of membrane damage. It enters the cell as an inactive form (a predrug) through passive transmission and is activated in either the cytoplasm of the bacteria or particular organelles in the protozoa [30]. Metronidazole is a nitroimidazole antibiotic, which is effective against anaerobic bacteria and protozoa (simon und stille, 1997).
What is the mechanism of action of metronidazole?
Its selective toxicity to anaerobic microbes involves 1. Ferredoxin oxidoreductase (pfor) enzyme pathway of pyruvate oxidation. Metronidazole, taken up by diffusion, is selectively absorbed by anaerobic bacteria and sensitive protozoa. Mode of action of metronidazole on anaerobic bacteria and protozoa.
Although its precise mechanism of action is unknown, available evidence indicates that it acts in a similar way as metronidazole—through nitroradicals generated by metabolism of the drug within target organism.
Reduction of nitro function into nitro anion radical and hydroxylamine which bind with dna causing single strand breaks. Mechanism of action metronidazole is of the nitroimidazole class. Vaginal fluid ph is > 4.5. Drug enters the cell by.
In anaerobic or microaerophilic bacteria or luminal parasites, metronidazole is activated when it receives an electron from ferredoxin or flavodoxin that was reduced by por (9, 36, 37, 40, 47, 61, 68, 72, 87, 88).
Metronidazole, another drug family member, has been suggested to affect photosynthesis by draining electrons from the electron carrier. Metronidazole exerts antibacterial effects in an anaerobic environment by the following possible mechanism: The energy metabolism of anaerobes is, thus, disrupted. Metronidazole, a nitroimidazole, exerts antibacterial effects in an anaerobic environment against most obligate anaerobes.
Metronidazole diffuses into the organism, inhibits protein synthesis by interacting with dna and causing a loss of helical dna structure and strand breakage.
Resistance is uncommon except in regions of southeast asia where there are high rates of multidrug resistance. Mechanism of action of metronidazole. Metronidazole is sensitive against almost obligate anaerobic bacteria, and against protozoa such as trichomonas, giardia lamblia and entamoeba. Metronidazole is the drug of choice for treating all forms of amoebiasis (intestinal amoebiasis, amoebic dysentery and amoebic liver abscess) due to its marked action on both luminal and tissue forms of e.
There are clue cells with a stippled appearance on the outer margins on microscopic testing of the vaginal fluid.
Metronidazole diffuses into the organism, inhibits protein synthesis by interacting with dna and causing a loss of helical dna structure and strand breakage. Metronidazole is effective against a diversity of protozoa and obligate anaerobic bacteria [30, 31]. Nucleic acid amplification testing for gonorrhea and chlamydia is negative. Exerts action on susceptible organisms in four successive stages:
Penetrates readily into protozoan and bacterial cells but not mammalian cells.
An amine whiff test enhances the fishy odor. The nitro radical of metronidazole acts as an electron sink which competes with the biological electron acceptors of the anaerobic organism for the electrons generated by the pyruvate : The nitro group of metronidazole is chemically reduced by ferredoxin and the products are responsible for disrupting the dna helical structure, thus. She is started on metronidazole.
Once metronidazole enters the organism by passive.
Entry of the drug into the organism, its reductive activation, interaction of the reduced intermediate products with intracellular targets, and breakdown of the toxic intermediate products.
